Very fast Suzuki–Miyaura reaction catalyzed by Pd (OAc) 2 under aerobic conditions at room temperature in EGME/H2O

A Del Zotto, F Amoroso, W Baratta…

Index: Del Zotto, Alessandro; Amoroso, Francesco; Baratta, Walter; Rigo, Pierluigi European Journal of Organic Chemistry, 2009 , # 1 p. 110 - 116

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Citation Number: 26

Abstract

Abstract The results of a ligand-free Pd (OAc) 2-catalyzed Suzuki–Miyaura C–C coupling performed at room temperature under aerobic conditions are presented. It was found that the use of an ethylene glycol monomethyl ether/H 2 O mixture as the solvent resulted in very rapid reactions of aryl bromides with arylboronic acids. As a matter of fact, under optimized conditions, some substrates were converted quantitatively in less than 1 min with ...