One Pot Synthesis of Nitriles from Aldehydes and Hydroxylamine Hydrochloride Using Ferrous Sulphate in DMF Under Reflux Condition

…, GC Wadhava, AK Deshmukh

Index: Patil, Dinanath D.; Wadhava, Gurumeet C.; Deshmukh, Arun K. Asian Journal of Chemistry, 2012 , vol. 24, # 3 p. 1401 - 1402

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Abstract

Nitriles are widely used for transformation into amides amines, esters, carboxylic acid etc.1 hence they have been used as intermediates for the synthesis of fine chemicals such as agricultural chemicals, dyes and medicines2. One of the most general methods for the synthesis of nitriles is the nucleophilic substitution reaction of alkylhalide with metal cyanides. The method is however inconvenient because of high toxicity of metal cyanides and their trouble in handling. ...