The reactions of individual molar solutions of D-glucose, D-mannose and D-fructose in 0.035 N sodium hydroxide at 35'have been studied using radioisotopic dilution analysis for D-glucose and D-fructose in the reaction mixtures and a corrected phenylhydrazone precipitation procedure for D-mannose. After reaction times of four to eight weeks, summation of the analyses for these three isomeric sugars accounted in each instance for ...