New biocatalytic route for the production of enantioenriched β-alanine derivatives starting from 5-and 6-monosubstituted dihydrouracils

…, FJ Las Heras-Vázquez, S Martínez-Rodríguez

Index: Martinez-Gomez, Ana Isabel; Clemente-Jimenez, Josefa Maria; Rodriguez-Vico, Felipe; Kanerva, Liisa T.; Li, Xiang-Guo; Heras-Vazquez, Francisco Javier Las; Martinez-Rodriguez, Sergio Process Biochemistry, 2012 , vol. 47, # 12 p. 2090 - 2096

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Citation Number: 2

Abstract

Taking advantage of the catalytic promiscuity of pyrimidine-catabolism enzymes (dihydropyrimidinase (EC 3.5. 2.2), N-carbamoyl-β-alanine amidohydrolase (EC 3.5. 1.6)), the production of different β-alanine derivatives starting from 5-and 6-monosubstituted dihydrouracils has been evaluated using a mimesis approach. In this work, the S- enantioselective character of dihydropyrimidinase from Sinorizhobium meliloti toward 6- ...