Enantioselective syntheses of isotopically labelled α??amino acids. Preparation of (ϵ??13C)??L?螃窿?aminoadipic acid and five isotopomers of L??lysine with 13C, 15N and …

…, CM van der Wielen, J Lugtenburg

Index: Raap, J.; Wielen, C. M. van der; Lugtenburg, J. Recueil des Travaux Chimiques des Pays-Bas, 1990 , vol. 109, # 4 p. 277 - 286

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Citation Number: 14

Abstract

Abstract An asymmetric synthesis of the six-carbon α-amino acids (ϵ-13 C)-L-α-aminoadipic acid and various isotopomers of L-lysine is described. The synthesis is based on a general method starting from the bis-lactim ether of cyclo (D-Val-Gly) and simple labelled reagents like K 13 CN, K 13 C 15 N, 13 CH 3 CN and LiAl 2 H 4. Using this route (ϵ-13 C)-L-α- aminoadipic acid was prepared in 31% yield based on the labelled potassium cyanide. ...