Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity

BR Kusuma, L Zhang, T Sundstrom…

Index: Olson, Jeremy P.; Gichinga, Moses G.; Butala, Elizabeth; Navarro, Hernan A.; Gilmour, Brian P.; Carroll, F. Ivy Organic and Biomolecular Chemistry, 2011 , vol. 9, # 11 p. 4276 - 4286

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Citation Number: 16

Abstract

... a Reagents and conditions: (a) NaHCO 3 , BnBr, CH 3 CN, rt, 75%; (b) Tf 2 O, Et 3 N, CH 2 Cl 2 , 60%; (c) 4a–p, Pd(PPh 3 ) 4 , K 2 CO 3 , DMF, 65–92%; (d) TBSCl, imid, CH 2 Cl 2 ; (e) CH 3 NO 2 , NH 4 OAc, 90–98%; (f) LiAlH 4 , THF, 0 °C-rt, 30 min; (g) Ac 2 O, Et 3 N, 61 ...