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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents

DTW Chu, PB Fernandes, AK Claiborne…

Index: Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564

Full Text: HTML

Citation Number: 164

Abstract

... Chem. 1984,27, 292. 0022-2623/85/ 1828-1558$01.50/0 0 1985 American Chemical Society Page 2. Arylfluoroquinolone Antibacterial Agents Journal of Medicinal Chemistry, 1985, Vol. 28, No. 11 1559 Scheme I ...

 Related Synthetic Route
N/A Structure

98106-00-4

N/A

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

1-(2,4-Dichloro-5-fluorophenyl)ethanone Structure

704-10-9

1-(2,4-Dichloro...

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

Benzenepropanoic acid,2,4-dichloro-5-fluoro-b-oxo-, ethyl ester Structure

86483-51-4

Benzenepropanoi...

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Structure

98105-79-4

7-Chloro-6-fluo...

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester Structure

98105-80-7

1-(4'-fluoro-ph...

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

ethyl 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxobenzenepropanoate Structure

98105-65-8

ethyl 2,4-dichl...

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

(Z)-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-3-ETHOXY-ACRYLIC ACID ETHYL ESTER Structure

86483-52-5

(Z)-2-(2,4-DICH...

~%

Sarafloxacin Structure

98105-99-8

Sarafloxacin

1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester Structure

98105-80-7

1-(4'-fluoro-ph...

~%

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Structure

98105-79-4

7-Chloro-6-fluo...

1-(2,4-Dichloro-5-fluorophenyl)ethanone Structure

704-10-9

1-(2,4-Dichloro...

~%

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Structure

98105-79-4

7-Chloro-6-fluo...

Benzenepropanoic acid,2,4-dichloro-5-fluoro-b-oxo-, ethyl ester Structure

86483-51-4

Benzenepropanoi...

~%

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Structure

98105-79-4

7-Chloro-6-fluo...

ethyl 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxobenzenepropanoate Structure

98105-65-8

ethyl 2,4-dichl...

~%

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Structure

98105-79-4

7-Chloro-6-fluo...

(Z)-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-3-ETHOXY-ACRYLIC ACID ETHYL ESTER Structure

86483-52-5

(Z)-2-(2,4-DICH...

~%

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Structure

98105-79-4

7-Chloro-6-fluo...

1-(2,4-Dichloro-5-fluorophenyl)ethanone Structure

704-10-9

1-(2,4-Dichloro...

~%

Difloxacin Structure

98106-17-3

Difloxacin

Benzenepropanoic acid,2,4-dichloro-5-fluoro-b-oxo-, ethyl ester Structure

86483-51-4

Benzenepropanoi...

~%

Difloxacin Structure

98106-17-3

Difloxacin

1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester Structure

98105-80-7

1-(4'-fluoro-ph...

~%

Difloxacin Structure

98106-17-3

Difloxacin

ethyl 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxobenzenepropanoate Structure

98105-65-8

ethyl 2,4-dichl...

~%

Difloxacin Structure

98106-17-3

Difloxacin

(Z)-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-3-ETHOXY-ACRYLIC ACID ETHYL ESTER Structure

86483-52-5

(Z)-2-(2,4-DICH...

~%

Difloxacin Structure

98106-17-3

Difloxacin

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Detail Synthetic Route


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