Design of polymeric inhibitors for the control of crystal polymorphism. Induced enantiomeric resolution at racemic histidine by crystallization at 25. degree. C

…, D Zbaida, L Addadi, L Leiserowitz…

Index: Weissbuch, I.; Zbaida, D.; Addadi, L.; Leiserowitz, L.; Lahav, M. Journal of the American Chemical Society, 1987 , vol. 109, # 6 p. 1869 - 1871

Full Text: HTML

Citation Number: 77

Abstract

2 H), 7.05 (m, 8 H), 7.40 (s, 2 H). Conversion of 9 to 10 was accomplished by hydrogenation over 10% Pd-C using EtOAc as solvent. Compound 10 was not isolated and was oxidized directly with R u O~. H~ ON~ IO,~~ to ester 11 in 44% overall yield from 9. Hydrogenation of 12* over 10% Pd-C also yielded 11, which formed colorless crystals" from cyclohexane: mp 155-156 OC;'H NMR (CDCI,) 6 2.90 (s, 4 H), 3.50 (s, 6 H), 6.80-7.15 (m, 8 H), 7.90 (s, 2 H). ...