Journal of fluorine chemistry

Synthesis of 3, 4-difluorobenzonitrile and monofluorobenzonitriles by means of halogen-exchange fluorination

H Suzuki, Y Kimura

Index: Suzuki, Hiroshi; Kimura, Yoshikazu Journal of Fluorine Chemistry, 1991 , vol. 52, # 3 p. 341 - 351

Full Text: HTML

Citation Number: 23

Abstract

Abstract 3, 4-Difluorobenzonitrile has been prepared by a halogen-exchange reaction between 3, 4-dichlorobenzonitrile and spray-dried potassium fluoride in the presence of tetraphenylphosphonium bromide in refluxing 1, 3-dimethylimidazolidine-2-one. In the fluorination reaction, 4-chloro-3-fluorobenzonitrile seems to be a key intermediate.