Bioorganic & medicinal chemistry letters

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

IR Baxendale, SV Ley

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 17 p. 1983 - 1986

Full Text: HTML

Citation Number: 106

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The unprecedented opportunities for medicinal chemistry arising from high-throughput screening and genomics programmes is driving ... 2 have been developed which combine the advantages of substrate supported chemistry with the ...

 Related Synthetic Route
4-Amino-1-methyl-3-N-propyprzole-5-carboxamide Structure

139756-02-8

4-Amino-1-methy...

~%

Sildenafil Structure

139755-83-2

Sildenafil

2-Hydroxy-5-[(4-methylpiperazin-4-ium-1-yl)sulfonyl]benzoate Structure

960009-35-2

2-Hydroxy-5-[(4...

~%

Sildenafil Structure

139755-83-2

Sildenafil

methylpiperazine Structure

109-01-3

methylpiperazine

~%

Sildenafil Structure

139755-83-2

Sildenafil

5-Chlorosulfonyl-2-hydroxy-benzoic acid Structure

17243-13-9

5-Chlorosulfony...

~%

Sildenafil Structure

139755-83-2

Sildenafil

ethyl 2-(2-(1-cyanobutyl)-1-methylhydrazinyl)acetate Structure

304435-81-2

ethyl 2-(2-(1-c...

~%

Sildenafil Structure

139755-83-2

Sildenafil

ethyl 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxylate Structure

304435-83-4

ethyl 4-amino-1...

~%

Sildenafil Structure

139755-83-2

Sildenafil

ethyl 2-(2-(1-cyanobutyl)-1-methylhydrazinyl)acetate Structure

304435-81-2

ethyl 2-(2-(1-c...

~%

4-Amino-1-methyl-3-N-propyprzole-5-carboxamide Structure

139756-02-8

4-Amino-1-methy...

Methanol Structure

67-56-1

Methanol

ethyl 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxylate Structure

304435-83-4

ethyl 4-amino-1...

~%

4-Amino-1-methyl-3-N-propyprzole-5-carboxamide Structure

139756-02-8

4-Amino-1-methy...

1H-Pyrazole-5-carboxylicacid,4-amino-1-methyl-3-propyl-,methylester(9CI) Structure

727408-28-8

1H-Pyrazole-5-c...

methylpiperazine Structure

109-01-3

methylpiperazine

~%

4-METHYLPHENYLDIIODOMETHYLSULFONE Structure

200575-15-1

4-METHYLPHENYLD...

5-Chlorosulfonyl-2-hydroxy-benzoic acid Structure

17243-13-9

5-Chlorosulfony...

~%

4-METHYLPHENYLDIIODOMETHYLSULFONE Structure

200575-15-1

4-METHYLPHENYLD...

ethyl 2-(2-(1-cyanobutyl)-1-methylhydrazinyl)acetate Structure

304435-81-2

ethyl 2-(2-(1-c...

~%

4-METHYLPHENYLDIIODOMETHYLSULFONE Structure

200575-15-1

4-METHYLPHENYLD...

ethyl 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxylate Structure

304435-83-4

ethyl 4-amino-1...

~%

4-METHYLPHENYLDIIODOMETHYLSULFONE Structure

200575-15-1

4-METHYLPHENYLD...


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