Abstract N-Glycyl-(1R, 3S)-1-(m-hydroxybenzyl)-1, 2, 3, 4-tetrahydroisoquinoline-3- carboxylic acid (Tic) was prepared as a Tyr-Tic dipeptide mimetic for exploration of its potential as a delta opioid receptor selective ligand. The compound was successfully obtained by a stereoselective synthesis starting from L-Tic. In the course of the reactions, unusual peptide bond cleavages were observed under mild conditions, and reaction ...
