2-Phenyl-3H-imidazo [4, 5-b] pyridine-3-acetamides as nonbenzodiazepine anticonvulsants and anxiolytics

…, CR Taylor Jr, LM Moses, DB Sutherland…

Index: Tomczuk, Bruce E.; Taylor, C. R; Moses, L. Meredith; Sutherland, Deborah B.; Lo, Young S.; et al. Journal of Medicinal Chemistry, 1991 ,  vol. 34,  # 10  p. 2993 - 3006

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Citation Number: 63

Abstract

A series of 2-phenyl-3H-imidazo [4, 5-b] ppidine-3-acetamides were designed and synthesized as non-benzodiazepine anxiolytica bawd on a molecular disconnection of a typical 1, 4-benzodiazepine (BZD). A number of these compounds showed submicromolar potency in a [%] benzodiazepine binding assay in vitro and good potency in protecting rodents against pentylenetetrmle-induced seizures. Compound 84 appears to be a ...