Tetrahedron

… Synthesis and antitumor activity of α-and γ-substituted methotrexate analogs11For the previous paper, Part 6: T. Tsushima and K. Kawada, Tetrahedron Lett, 1985, 26 …

…, K Kawada, S Ishihara, N Uchida, O Shiratori, J Higaki…

Index: Tsushima; Kawada; Ishihara; Uchida; Shiratori; Higaki; Hirata Tetrahedron, 1988 ,  vol. 44,  # 17  p. 5375 - 5387

Full Text: HTML

Citation Number: 108

Abstract

Three types of reactions of α-substituted malonates, difluoromethylation, alkylation with n, n, n-trifluoroalkyl sulfonates, and Michael addition to 2-substituted-acrylates, conveniently afforded a number of fluorine containing α amino acids such as β-fluorinated-alanines, 2- amino-n, n, n-trifluoroalkanoic acids, and fluorinated glutamic acids as well as other γ- heteroatom substituted glutamic acids. Here, an efficient enzymatic optical resolution ...