Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl) piperidine-2, 6-diones

…, C Batzl, TM Pongratz, A Mannschreck

Index: Hartmann; Batzl; Pongratz; Mannschreck Journal of Medicinal Chemistry, 1992 ,  vol. 35,  # 12  p. 2210 - 2214

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Citation Number: 35

Abstract

(2)]. The enantiomers of 2 were separated either by using HPLC on optically active sorbent or by crystallization of the brucine salt of the phthalamic acid of 2. The absolute configuration of the (+)-and (-)-enantiomers of 2 were assigned as S and R, respectively, by comparing the CD spectra to those of the enantiomers of aminoglutethimide (AG, 3-(4-aminophenyl)-3- ethylpiperidine-2, 6-dione). The compounds were tested in vitro for inhibition of human ...