Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites

LG Humber, E Ferdinandi, CA Demerson…

Index: Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 9  p. 1712 - 1719

Full Text: HTML

Citation Number: 31

Abstract

The syntheses of five metabolites of the antiinflammatory drug etodolac (1, 8-diethyl-1, 3, 4, 9-tetrahydropyrano-[3, 4-b] indole-l-acetic acid) are described, viz. 6-hydroxyetodolac, N- methyletodolac, 4-ureidoetodolac, 8-(1'-hydroxy) etodolac, and 4-oxoetodolac. These syntheses were used to confirm the identities of the metabolites. The metabolites themselves, as well as the previously reported metabolite 7-hydroxyet~ dolac, were tested ...