A series of bis [[(carbamoyl) oxy] methyl]-substituted pyrrole-fused tricyclic heterocycles were synthesized by using 1, 3-dipolar cycloaddition reactions with a trifluoromethanesulfonate salt of an appropriate Resissert compound or with a mesoionic oxazolone intermediate. All of the bis (carbamates) were active in vivo against P388 lymphocytic leukemia with 5, 6- dihydrc-8-methoxy-l, 2-bis (hydroxymethyl) pyrrolo [2, la] isoquinoline bis [N-(2-propyl) ...
