Details of efficient syntheses of (9 S, 12 S)-cycloisodityrosine (6) and a concise total synthesis of RA-VII (1) were described. An intramolecular SNAr-based cycloetherification reaction was employed as the key ring-closure step for construction of the illusive 14- membered m, p-cyclophane. Treatment of methyl N-[N-(tert-butyloxycarbonyl)-l-(3-hydroxy-4- methoxyphenylalanyl]-l-4-fluoro-3-nitrophenylalaninate ((9 S, 12 S)-10) with potassium ...
