Synlett

Thionyl chloride-benzotriazole in methylene chloride: A convenient solution for conversion of alcohols and carboxylic acids expeditiously into alkyl chlorides and acid …

SS Chaudhari, KG Akamanchi

Index: Chaudhari, Sachin S.; Akamanchi, Krishnacharya G. Synlett, 1999 , # 11 p. 1763 - 1765

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Citation Number: 21

Abstract

Abstract: A solution of 1: 1 equivalent of thionyl chloride and benzotriazole in dry methylene chloride efficiently transforms alcohols and carboxylic acids into the corresponding alkyl chlorides and acid chlorides respectively at room temperature, with excellent yields by simple titration. Key words: benzotriazole, thionyl chloride, chlorination, alcohols, carboxylic acids

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