Iodine??Catalyzed, Stereo??and Regioselective Synthesis of 4??Arylidine??4H??benzo [d][1, 3] oxazines and their Applications for the Synthesis of Quinazoline 3??Oxides

…, WP Hu, WS Lo, C Murali, JK Vandavasi…

Index: Lee, Wen-Chun; Shen, Ho-Chuan; Hu, Wan-Ping; Lo, Wei-Sheng; Murali, Chebrolu; Vandavasi, Jaya Kishore; Wang, Jeh-Jeng Advanced Synthesis and Catalysis, 2012 ,  vol. 354,  # 11-12  p. 2218 - 2228

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Citation Number: 29

Abstract

Abstract 4-Benzylidene-2-aryl-4H-benzo [d][1, 3] oxazines have been synthesized with high stereoselectivity and regioselectivities from 2-alkynylbenzamides in the presence of a catalytic amount of I 2. In the reaction mechanism, iodine plays a key role in two different aspects as a catalyst, such as to activate the alkyne with the iodinium donor which triggers the cascade, and then as a proper acid source to facilitate catalyst recovery. The ...