Synlett

Total synthesis of (+)-camptothecin via an intramolecular palladium-catalyzed cyclization strategy

SP Chavan, AB Pathak, UR Kalkote

Index: Chavan, Subhash P.; Pathak, Ashok B.; Kalkote, Uttam R. Synlett, 2007 ,  # 17  p. 2635 - 2638

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Citation Number: 13

Abstract

A new synthetic approach towards 1, as depicted in Scheme [1] , was undertaken where (+)-1 could be accessed from enol ether 28 by Sharpless asymmetric dihydroxylation followed by oxidation. The enol ether in turn could be obtained from diester 25 by selective reduction of the heteroaromatic ester. The diester 25 could be accessed from compound 23 by alkylation and carboxylation, compound 23 could be obtained from olefin 22 by Pd-catalyzed cascade ...