The synthesis of the isomeric series 6-chloro-7-sulfamoyl-and 7-chloro-6-sulfamoyl-1 (2H)- phthalazinones (1 and 2) and 6-chloro-7-sulfamoyl-and 7-chloro-6-sulf~ oyl-3, 4-dihyd~ l (~- ph~ azinones (3 and 4), combining structural features characteristic to furosemide and hydralazine, is described, the mechanism of the formation of 1 and 2 is discussed, and their structure-activities relationships are studied. Preliminary screening in the rat shows that ...
