Abstract A practical synthesis of 2′-deoxy-2′-fluoro-5-methyl-β-L-arabinofuranosyl uracil (14 July 19, L-FMAU) was developed from L-arabinose. L-Arabinose was converted to L- ribose 5, which was used for the synthesis of bromosugar 12 via 2, 3, 5-O-tribenzoyl-1-O- acetyl-β-L-ribofuranose 8, which was subjected to condensation with silylated thymine and the resulting protected L-FMAU 13 was deprotected to afford L-FMAU in 14 steps in 8% ...
