The synthesis of novel constrained cis-peptidyl prolinamide mimetics for the dipeptide amides glycyl (2S)-prolinamide,(2S)-alanyl (2S)-prolinamide and (2R)-alanyl (2S) prolinamide and some analogues, based upon fused 1, 2, 5-triazepine-3, 6-diones, is described; these are suitable for elaboration into larger peptides at both the carboxy and amino termini, X-ray crystal structures for some of the compounds and intermediates are ...
![1H-Pyrrolo[2,1-d][1,2,5]triazepine-1,5(2H)-dione,hexahydro-,(S)-(9CI) Structure](https://image.chemsrc.com/caspic/074/175853-35-7.png)