Tetrahedron letters

Nucleoside 3′-N, N-dialkylphosphonamidates: novel building blocks for oligonucleotide synthesis

T Wada, K Ishikawa, T Hata

Index: Wada; Ishikawa; Hata Tetrahedron Letters, 1990 , vol. 31, # 44 p. 6363 - 6366

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Abstract

Abstract Nucleoside 3′-N, N-diisopropylphosphonamidates reacted with tris (2, 4, 6- tribromophenoxy) dichlorophosphorane (BDCP) to generate the corresponding aminophosphorochloridites without cleavage of the P N bond. The reaction was applied to