There have been important recent advances in radical chemistry, particularly in asymmetric synthesis. 1 We have reported a synthesis of chiral cycloalkenyl acetic acids using diastereoselective radical cyclization with 8-phenylmenthol as the chiral auxiliary (Scheme 1). 2 In this reaction, the presence of a bulky Lewis acid such as methylaluminum bis(2,6-di-t-butyl-4-methylphenoxide ) (MAD) 3 is essential for high selectivity. ... 8-Phenylmenthol is a cyclohexanol-type ...
