Pyrano-[2, 3b]-pyridines as potassium channel antagonists

HJ Finlay, J Lloyd, M Nyman, ML Conder, T West…

Index: Finlay, Heather J.; Lloyd, John; Nyman, Michael; Conder, Mary Lee; West, Tonya; Levesque, Paul; Atwal, Karnail Bioorganic and Medicinal Chemistry Letters, 2008 ,  vol. 18,  # 8  p. 2714 - 2718

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Citation Number: 11

Abstract

The design and synthesis of a series of highly functionalized pyrano-[2, 3b]-pyridines is described. These compounds were assayed for their ability to block the IKur channel encoded by the gene hKV1. 5 in patch-clamped L-929 cells. Six of the compounds in this series showed sub-micromolar activity, the most potent being 4-(4-ethyl- benzenesulfonylamino)-3-hydroxy-2, 2-dimethyl-3, 4-dihydro-2H-pyrano [2, 3b]-pyridine-6 ...