e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Diastereo??and Enantioselective Total Synthesis of Stigmatellin A

D Enders, G Geibel, S Osborne

Index: Enders, Dieter; Geibel, Gunter; Osborne, Simon Chemistry - A European Journal, 2000 , vol. 6, # 8 p. 1302 - 1309

Full Text: HTML

Citation Number: 39

Abstract

Abstract Stigmatellin A (1) isolated from the myxobacterium Stigmatella aurantiaca is a powerful inhibitor of electron transport in mitochondria and chloroplasts. The first highly diastereo-and enantioselective total synthesis of this important natural product is ...

1,1'-(2-Hydroxy-4,6-dimethoxy-1,3-phenylene)bis-1-propanone Structure

1,1'-(2-Hydroxy...

~%

1-(2,3-Dihydroxy-4,6-dimethoxyphenyl)-1-propanone Structure

1-(2,3-Dihydrox...

1-(2,3-Dihydroxy-4,6-dimethoxyphenyl)-1-propanone Structure

1-(2,3-Dihydrox...

~%

2-[(3S,4S,5S,6R)-7-Hydroxy-4,6-dimethoxy-3,5-dimethylheptyl]-5,7-dimethoxy-8-(MethoxyMethoxy)-3-Methyl-2,3-dihydro-4H-1-benzopyran-4-one Structure

2-[(3S,4S,5S,6R...

1,1'-(2-Hydroxy-4,6-dimethoxy-1,3-phenylene)bis-1-propanone Structure

1,1'-(2-Hydroxy...

~%

2-[(3S,4S,5S,6R)-7-Hydroxy-4,6-dimethoxy-3,5-dimethylheptyl]-5,7-dimethoxy-8-(MethoxyMethoxy)-3-Methyl-2,3-dihydro-4H-1-benzopyran-4-one Structure

2-[(3S,4S,5S,6R...

1-[2-Hydroxy-4,6-dimethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone Structure

1-[2-Hydroxy-4,...

~%

2-[(3S,4S,5S,6R)-7-Hydroxy-4,6-dimethoxy-3,5-dimethylheptyl]-5,7-dimethoxy-8-(MethoxyMethoxy)-3-Methyl-2,3-dihydro-4H-1-benzopyran-4-one Structure

2-[(3S,4S,5S,6R...

(4S,5S,6S,7R)-5,7-Dimethoxy-4,6-dimethyl-8-(phenylmethoxy)-1-octanol Structure

(4S,5S,6S,7R)-5...

~%

2-[(3S,4S,5S,6R)-7-Hydroxy-4,6-dimethoxy-3,5-dimethylheptyl]-5,7-dimethoxy-8-(MethoxyMethoxy)-3-Methyl-2,3-dihydro-4H-1-benzopyran-4-one Structure

2-[(3S,4S,5S,6R...

3-Chloropropyl 4-Methoxyphenyl Ether Structure

3-Chloropropyl ...

~%

(4S)-7-(4-Methoxyphenoxy)-4-Methyl-3-heptanone Structure

(4S)-7-(4-Metho...

3-Chloropropyl 4-Methoxyphenyl Ether Structure

3-Chloropropyl ...

~%

(2R,3R,5S)-3,5-Dimethyl-1-benzyloxy-2-hydroxy-8-(4-Methoxyphenoxy)-4-octanone Structure

(2R,3R,5S)-3,5-...

1,1'-(2-Hydroxy-4,6-dimethoxy-1,3-phenylene)bis-1-propanone Structure

1,1'-(2-Hydroxy...

~%

1-[2-Hydroxy-4,6-dimethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone Structure

1-[2-Hydroxy-4,...

(2R,3R,5S)-3,5-Dimethyl-1-benzyloxy-2-hydroxy-8-(4-Methoxyphenoxy)-4-octanone Structure

(2R,3R,5S)-3,5-...

~98%

(2R,3S,4S,5S)-3,5-Dimethyl-1-(benzyloxy)-8-(4-Methoxyphenoxy)-2,4-octanediol Structure

(2R,3S,4S,5S)-3...

3-Chloropropyl 4-Methoxyphenyl Ether Structure

3-Chloropropyl ...

~%

(2R,3S,4S,5S)-3,5-Dimethyl-1-(benzyloxy)-8-(4-Methoxyphenoxy)-2,4-octanediol Structure

(2R,3S,4S,5S)-3...

(4S)-7-(4-Methoxyphenoxy)-4-Methyl-3-heptanone Structure

(4S)-7-(4-Metho...

~%

(2R,3S,4S,5S)-3,5-Dimethyl-1-(benzyloxy)-8-(4-Methoxyphenoxy)-2,4-octanediol Structure

(2R,3S,4S,5S)-3...