1??Pentanoyl??N??{[2'??(1H??tetrazol??5??yl) biphenyl??4??yl] methyl}??pyrrolidine??2??carboxamide: Investigation of Structural Variations

A Catalano, A Carocci, A Di Mola, C Bruno…

Index: Catalano, Alessia; Carocci, Alessia; Di Mola, Antonia; Bruno, Claudio; Vanderheyden, Patrick M. L.; Franchini, Carlo Archiv der Pharmazie, 2011 , vol. 344, # 9 p. 617 - 626

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Citation Number: 5

Abstract

Abstract We recently reported a series of 1-acyl-N-(biphenyl-4-ylmethyl) pyrrolidine-2- carboxamides as AT 1 receptor ligands. The most potent compound of the series, 1- pentanoyl-N-{[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl}-pyrrolidine-2-carboxamide, showed an interesting affinity for the receptor. To investigate the influence of structure variations on affinity, the synthesis of additional compounds belonging to this series has been ...