A single??step preparation of thiazolo [5, 4??b] pyridine??and thiazolo [5, 4??c] pyridine derivatives from chloronitropyridines and thioamides, or thioureas

…, D Tan, S Zipfel, M Cox, DJR O'Mahony…

Index: Sahasrabudhe, Kiran P.; Estiarte, M. Angels; Tan, Darlene; Zipfel, Sheila; Cox, Matthew; O'Mahony, Donogh J. R.; Edwards, William T.; Duncton, Matthew A. J. Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 6 p. 1125 - 1131

Full Text: HTML

Citation Number: 4

Abstract

The thiazolo [5, 4-b] pyridine nucleus is of interest to those working in the agrochemical, pharmaceutical, and materials industries [1]. For instance, compounds containing a thiazolo [5, 4-b] pyridine substructure have been described as ligands, or modulators, of leukotriene A4 [2], VEGFR-2 [3], p38 MAP kinase [4], CCR3 [5], IAP [6], PPAR [7], D4 [8], ubiquitin ligase [9], glucokinase [10], JAK3 [11], and sirtuin [12] amongst others [13]. A number of methods ...