Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2

K Takeuchi, WG Holloway, CH Mitch, SJ Quimby…

Index: Takeuchi, Kumiko; Holloway, William G.; Mitch, Charles H.; Quimby, Steven J.; McKinzie, Jamie H.; Suter, Todd M.; Statnick, Michael A.; Surface, Peggy L.; Emmerson, Paul J.; Thomas, Elizabeth M.; Siegel, Miles G. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6841 - 6846

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Citation Number: 15

Abstract

A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2, 3, 4, 5-tetrahydro-1H-benzo [c] azepin-7-yloxy) nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.