Evolution of a novel series of [(N, N-dimethylamino) propyl]-and piperazinylbenzanilides as the first selective 5-HT1D antagonists

…, IB Campbell, MC Carter, EW Collington…

Index: Clitherow; Scopes; Skingle; Jordan; Feniuk; Campbell; Carter; Collington; Connor; Higgins; Beattie; Kelly; Mitchell; Oxford; Wadsworth; Tyers Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2253 - 2257

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Citation Number: 97

Abstract

Central 5-hydroxytryptamine (5-HT) receptors have been classified into four main families: 5- HT1, 5-HT2, 5-HT3, and 5-HT4, 2-7 although others, such as 5-HT5, 5-HT6, and 5-HT7, have been identified from cloning studies. 8-10 The 5-HT1 family comprises subtypes~-HT~ A, B-HT~ B,~-HT~ D, 5-HTl~, ll-l~ and 5-HT l~ l~(the 5-HTlc receptor has been reclassified as a member of the 5-HT2 family). The~-HT~ D receptor has recently attracted ...