One??Pot Hydroxy Group Activation/Carbon??Carbon Bond Forming Sequence Using a Brønsted Base/Brønsted Acid System

A Devineau, G Pousse, C Taillier…

Index: Devineau, Alice; Pousse, Guillaume; Taillier, Catherine; Blanchet, Jerome; Rouden, Jacques; Dalla, Vincent Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2881 - 2886

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Citation Number: 13

Abstract

Abstract A new sequential two-step multicatalytic strategy is presented consisting in the efficient DBU-catalysed trichloroacetimidation of an alcohol followed by a ditriflylamine (Tf 2 NH)-catalysed intermolecular alkylation by silicon-based nucleophiles and C [BOND] H nucleophiles. The distinct feature of the trichloroacetimidate group allows use of weaker acid catalysts such as 1, 1′-bi-2-naphthol (BINOL)-derived phosphoric acid, pointing out the ...