A new, convenient and high yielding procedure for the preparation of diethyl α- aminophosphonates in water by one-pot reaction of aldehydes, amines, tri/dialkyl phosphites in the presence of a low catalytic amount of [Cu (3, 4-tmtppa)](MeSO4) 4 (0.16 mol%) as a highly stable and re-usable catalyst is described.
![N-[di(propan-2-yloxy)phosphoryl-phenylmethyl]aniline Structure](https://image.chemsrc.com/caspic/226/21234-61-7.png)
