Chemical Communications

Catalytic decarboxylative alkylation of β-keto acids with sulfonamides via the cleavage of carbon–nitrogen and carbon–carbon bonds

CF Yang, JY Wang, SK Tian

Index: Yang, Cui-Feng; Wang, Jian-Yong; Tian, Shi-Kai Chemical Communications, 2011 , vol. 47, # 29 p. 8343 - 8345

Full Text: HTML

Citation Number: 43

Abstract

While β-keto esters have been widely employed as carbon nucleophiles to couple with a broad range of carbon electrophiles in carbon–carbon bond-forming reactions, the corresponding β-keto acids have received relatively little attention in this respect. Sporadic examples show that under appropriate conditions β-keto acids are capable of undergoing decarboxylative carbon–carbon bond-forming reactions with carbon electrophiles such as aldehydes, 1 ...