2-Amino-5-aryl-2-oxazolines. Potent new anorectic agents

GI Poos, JR Carson, JD Rosenau…

Index: Poos,G.I. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 266 - 272

Full Text: HTML

Citation Number: 71

Abstract

A series of L'-aiiiino-j-: tr? l-2-oxnzolines was found to have potent: Lppetite siipprcmant activity. syntliesis, chemical behavior, and etructure-activity relationships for these compounds are described..\ l (~ tlioda of 111 pursuit oi our iiiterests iii cyclic pseudoureas as poteiitial pharmacological agents, I we prepared several representative substituted'-amiiio-"- oxazoliiies. Oiie of these conipouiids, 2-aiiiiiio-~-plieiiyI-'L-oxazoliii~~(I), was showii iii ...

 Related Synthetic Route
trans-4-Methylaminorex Structure

2077-59-0

trans-4-Methyla...

~%

1-phenylpropan-2-ylurea Structure

33061-37-9

1-phenylpropan-...

Phenylpropanolamine Structure

14838-15-4

Phenylpropanolamine

~%

1-phenylpropan-2-ylurea Structure

33061-37-9

1-phenylpropan-...

N/A Structure

13312-83-9

N/A

~%

2-Oxazolamine,5-(4-chlorophenyl)-4,5-dihydro- Structure

3876-10-6

2-Oxazolamine,5...

2-Amino-1-(4-chlorophenyl)ethanol Structure

41870-82-0

2-Amino-1-(4-ch...

Cyanogen bromide Structure

506-68-3

Cyanogen bromide

~%

2-Oxazolamine,5-(4-chlorophenyl)-4,5-dihydro- Structure

3876-10-6

2-Oxazolamine,5...

2-(2-chlorophenyl)-2-hydroxyacetonitrile Structure

13312-84-0

2-(2-chlorophen...

~%

2-Amino-1-(2-chlorophenyl)ethanol Structure

23496-56-2

2-Amino-1-(2-ch...

Mandelonitrile Structure

532-28-5

Mandelonitrile

~%

(2-hydroxy-2-phenylethyl)urea Structure

25017-52-1

(2-hydroxy-2-ph...

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

(2-hydroxy-2-phenylethyl)urea Structure

25017-52-1

(2-hydroxy-2-ph...

phenylethanolamine Structure

7568-93-6

phenylethanolamine

~%

(2-hydroxy-2-phenylethyl)urea Structure

25017-52-1

(2-hydroxy-2-ph...

aminorex Structure

2207-50-3

aminorex

~%

(2-hydroxy-2-phenylethyl)urea Structure

25017-52-1

(2-hydroxy-2-ph...

2-(4-bromophenyl)-2-hydroxyacetonitrile Structure

58289-69-3

2-(4-bromopheny...

~%

5-(4-Bromophenyl)-4,5-dihydro-1,3-oxazol-2-amine Structure

10145-39-8

5-(4-Bromopheny...

Cyanogen bromide Structure

506-68-3

Cyanogen bromide

2-Amino-1-(4-bromophenyl)ethanol Structure

41147-82-4

2-Amino-1-(4-br...

~%

5-(4-Bromophenyl)-4,5-dihydro-1,3-oxazol-2-amine Structure

10145-39-8

5-(4-Bromopheny...

2-hydroxy-2-[4-(trifluoromethyl)phenyl]acetonitrile Structure

168013-75-0

2-hydroxy-2-[4-...

~%

5-[4-(Trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazol-2-amine Structure

720-76-3

5-[4-(Trifluoro...

2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine Structure

81561-66-2

2-hydroxy-2-(4-...

Cyanogen bromide Structure

506-68-3

Cyanogen bromide

~%

5-[4-(Trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazol-2-amine Structure

720-76-3

5-[4-(Trifluoro...

Mandelonitrile Structure

532-28-5

Mandelonitrile

~%

aminorex Structure

2207-50-3

aminorex

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

aminorex Structure

2207-50-3

aminorex

Cyanogen bromide Structure

506-68-3

Cyanogen bromide

phenylethanolamine Structure

7568-93-6

phenylethanolamine

~%

aminorex Structure

2207-50-3

aminorex

1-cyano-1-(4-fluorophenyl)methanol Structure

133721-87-6

1-cyano-1-(4-fl...

~%

2-Amino-1-(4-fluorophenyl)ethanol Structure

456-05-3

2-Amino-1-(4-fl...

nitromethane Structure

75-52-5

nitromethane

4-Fluorobenzaldehyde Structure

459-57-4

4-Fluorobenzaldehyde

~%

2-Amino-1-(4-fluorophenyl)ethanol Structure

456-05-3

2-Amino-1-(4-fl...


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