Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone

…, BM Gandecha, M Partridge, LH Patterson…

Index: Islam, Suhail A.; Neidle, Stephen; Gandecha, Bijukumar M.; Partridge, Malcolm; Patterson, Laurence H.; Brown, Jeffrey R. Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 857 - 864

Full Text: HTML

Citation Number: 88

Abstract

As there is now a greater understanding of the DNA-intercalation process for dox~ rubicin'~ J~ and other compound~,'~ we can begin a more rational approach to the engineering of drugs to interact with DNA. In the present study we have evaluated the validity of such an approach.