Rare-earth metal chlorides as efficient catalysts for the simple and green synthesis of 1, 2-disubstituted benzimidazoles and 2-substituted benzothiazoles under …

LJ Zhang, J Xia, YQ Zhou, H Wang…

Index: Zhang, Li-Jun.; Xia, Jing; Zhou, Yong-Qing; Wang, Hua; Wang, Shao-Wu. Synthetic Communications, 2012 , vol. 42, # 3 p. 328 - 336

Full Text: HTML

Citation Number: 15

Abstract

Benzimidazoles, benzothiazoles, and their derivatives are very important intermediates for the biological activity of anti-ulcerative, anticancer, and antihistamine drugs. The traditional methodologies for synthesis of benzimidazoles involve the condensation of o-phenylenediamine with carboxylic acid, carboxylic acid derivatives, or aldehydes. [ 1 1. (a) Wang , R. ; Lu , XX ; Yu , XQ ; Shi , L. ; Sun , Y. Acid-catalyzed solvent-free synthesis of 2-arylbenzimidazoles under microwave ...