Tetrahedron

The total synthesis of desferrioxamines E and G

RJ Bergeron, JS McManis

Index: Bergeron, R. J.; McManis, J. S. Tetrahedron, 1990 , vol. 46, # 17 p. 5881 - 5888

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Citation Number: 21

Abstract

The total syntheses of the hexacoordinate amino acid, 32-amino-5, 16, 27-trihydroxy-4, 12, 15, 23, 26-pentaoxo-5, 11, 16, 22, 27-pentaazadotriacontanoic acid (desferrioxamine G) and the corresponding macrocyclic lactam 1, 12, 23-trihydroxy-1, 6, 12, 17, 23, 28- hexaazacyclotritriacontane-2, 5, 13, 16, 24, 27-hexone (desferrioxamine E, nocardamine) are reported. The synthetic route utilized here is predicated on the efficient formation and ...