The Journal of Organic Chemistry

Synthesis of α-Keto Acids from Diethyl Alkylidenemalonates

M Igarashi, H Midorikawa

Index: Igarashi,M.; Midorikawa,H. Journal of Organic Chemistry, 1964 , vol. 29, p. 2080 - 2082

Full Text: HTML

Citation Number: 2

Abstract

The epoxy ester (IIb), on treatment with alcoholic potassiuni hydroxide, gave a potassium salt of 2-carboxy-2, 3-epoxycaproic acid. The epoxy acid produced by acidification of the salt was decarboxylated on heating in an oil bath, giving 2-oxocaproic acid, identical (physical constants, infrared spectrum, and oxime derivative) with the compound prepared previously from a-oxocaproande.