Methylaluminum bis (2, 6-di-tert-butyl-4-alkylphenoxide). A new reagent for obtaining unusual equatorial and anti-Cram selectivity in carbonyl alkylation

K Maruoka, T Itoh, H Yamamoto

Index: Maruoka, Keiji; Itoh, Takayuki; Yamamoto, Hisashi Journal of the American Chemical Society, 1985 , vol. 107, # 15 p. 4573 - 4576

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Citation Number: 144

Abstract

The carbonyl alkylation process has long been studied, and constitutes one of the most fundamental bond constructions in organic synthesis.'In contrast to the recent, extensive efforts in this area for the development of a stereoselective alkylating agent for obtaining axial alcohols from cyclohexanones, 2 there exists no reliable methodology available for the selective synthesis of equatorial alcohol^.^ Here we describe (I conceptually new ...