New route to the synthesis of the isocryptolepine alkaloid and its related skeletons using a modified Pictet–Spengler reaction

PK Agarwal, D Sawant, S Sharma…

Index: Agarwal, Piyush K.; Sawant, Devesh; Sharma, Sunil; Kundu, Bijoy European Journal of Organic Chemistry, 2009 , # 2 p. 292 - 303

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Citation Number: 36

Abstract

Abstract A new route to the synthesis of the isocryptolepine alkaloid with antimalarial activity using a modified Pictet–Spengler reaction has been devised. The strategy was then used to generate libraries based on three structural variants of the alkaloid. Compounds based on these three variants in general were accessed in three steps through a modified Pictet– Spengler cyclization reaction as the key step. The C-2-, C-3-, or N-1-linked (aminoaryl) ...