Design and Synthesis of Some New N-Phenylanthranilic Acids from Highly Sterically Hindered Anilines

…, G Chen, S Qiao, R Liang, C Lan, Z Xia

Index: Li, Zhenghua; Chen, Gang; Qiao, Shu; Liang, Ronghui; Lan, Cong; Xia, Zhining Synthetic Communications, 2013 , vol. 43, # 9 p. 1270 - 1279

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Abstract

N-Phenylanthranilic acids, such as mefenamic acid, are important nonsteroidal anti-inflammatory drugs (NSAIDs) [ 1 1. Baures , PW ; Oza , VB ; Peterson , SA ; Kelly , JK Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the nonsteroidal anti-inflammatory drug, flufenamic acid . Bioorg. Med. Chem. 1999 , 7 , 1339 – 1347 . [CrossRef], [PubMed] View all references ] and crucial intermediates for the synthesis of acridones and acridines, ...