Journal of Heterocyclic Chemistry

Facile acidic hydrolysis and displacement reactions of 2??chloro??and 2, 9??dichloro??1, 10??phenanthroline

AP Krapcho, S Sparapani

Index: Krapcho, A. Paul; Sparapani, Silvia Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 4 p. 1167 - 1170

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Citation Number: 3

Abstract

Our interest in the synthesis of analogues with 1, 10-phenanthroline chromophores is based on their potential applications as inhibitors of telomerase, an enzyme found in tumor cells which control the continued growth of malignant tumors [1]. For example a platiniumphenanthroline complex has been reported as an inhibitor of telomerase [2]. Recently we have reported a convenient and multigram synthetic pathway to 2-chloro-(1a) ...