Synthesis and Structures of Se Analogues of the Antithyroid Drug 6??n??Propyl??2??thiouracil and Its Alkyl Derivatives: Formation of Dimeric Se–Se Compounds and …

…, N Hadjiliadis, A Papakyriakou, M Baril…

Index: Antoniadis, Constantinos D.; Hadjikakou, Sotiris K.; Hadjiliadis, Nick; Papakyriakou, Athanasios; Baril, Martin; Butler, Ian S. Chemistry - A European Journal, 2006 , vol. 12, # 26 p. 6888 - 6897

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Citation Number: 23

Abstract

Abstract Four selenium analogues of the antithyroid drug 6-n-propyl-2-thiouracil (PTU), of formulae RSeU,(R= methyl (Me)(1), ethyl (Et)(2), n-propyl (nPr)(3), and isopropyl (iPr) 4), have been synthesized. Reaction of 1–4 with diiodine in a 1: 1 molar ratio in dichloromethane results in the formation of [(RSeU) I 2](R= methyl (5), ethyl (6), n-propyl (7) and isopropyl (8)). All compounds have been characterized by elemental analysis, FT- ...