Hydrolysis and hydrogenolysis of formamidines: N, N-dimethyl and N, N-dibenzyl formamidines as protective groups for primary amines

S Vincent, C Mioskowski, L Lebeau

Index: Vincent, Stephane; Mioskowski, Charles; Lebeau, Luc Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 991 - 997

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Citation Number: 40

Abstract

Protective groups play a pivotal role in the synthesis of complex organic substances. 1 A number of reagents and procedures have been described to specifically protect and deprotect primary amines. N, N-Dialkyl formamidines and especially N, N-dimethyl formamidines have been widely used as protective groups for the exocyclic amino function of nucleosides. 2-12 Recently, we described the use of N, N-dibenzyl formamidine as a ...