Synthesis and biological evaluation of 3-benzyl-1-methyl-and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS

…, S Marzocco, C Vicidomini, C Saturnino…

Index: Paesano, Nicola; Marzocco, Stefania; Vicidomini, Caterina; Saturnino, Carmela; Autore, Giuseppina; De Martino, Giovanni; Sbardella, Gianluca Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 539 - 543

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Citation Number: 13

Abstract

Novel benzyl-and phenyl-isothioureidic derivatives have been synthesised and evaluated as inhibitors of nitric oxide synthesis, induced in lipopolysaccharide (LPS)-activated J774. A1 macrophage cell line. The most potent iNOS inhibitor resulting was 1-methyl-3-phenyl-S- methyl isothiourea 5l.