Enantioselective synthesis and absolute configuration of (−)-1-(benzofuran-2-yl)-2-propylaminopentane,((−)-BPAP), a highly potent and selective catecholaminergic …

…, T Yasusa, T Ando, M Watanabe, F Yoneda…

Index: Oka, Takahiro; Yasusa, Takuya; Ando, Takashi; Watanabe, Mayumi; Yoneda, Fumio; Ishida, Toshimasa; Knoll, Joseph Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1213 - 1219

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Citation Number: 24

Abstract

Enantioselective synthesis and absolute configuration of (−)-1-(benzofuran-2-yl)-2- propylaminopentane ((−)-BPAP), which is a highly potent and selective catecholaminergic activity enhancer (CAE) substance, are described. The synthetic approach consists of the coupling reaction of benzofuran with (R)-N-tosyl-2-propylazirizine or (R)-N-methoxy-N- methylnorvaliamide, followed by appropriate modifications of the resulting coupling ...