Tetramisole analogs as inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines

KK Bhargava, MH Lee, YM Huang…

Index: Bhargava,K.K. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 563 - 566

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Citation Number: 20

Abstract

Journal of Medicinal Chemistry, 1977, Vol. 20, No. 4 563 mixture was stirred at-25" C for 30 min. A chilled solution of bis (Me3-6-APA)[from 4.3 g (0.02 mol) of 6-APA and hexamethyldisilazine] in CHCl:,(50 mL) was added and the mixture was stirred at-20" C for 1 h and allowed to come to room temperature. Dioxane (100 mL) was added, and the mixture was filtered. Water (0.2 mL) was added to the filtrate; the mixture was stirred for 30 min ...