A highly effective procedure is reported to synthesize a substituted bicyclo [4.2. 0] octenol derivative by regioselective cycloaddition of phenyl-1-propynyl sulfide with cyclohexenone followed by selective reduction of the ketone group and reductive elimination of phenylsulfonyl group. The strained cyclobutene ring was then engaged in a ring- opening/cross metathesis sequence in the presence of Hoveyda–Grubbs 2nd generation ...
