e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

3-Phenylpiperidines. Central dopamine-autoreceptor stimulating activity

U Hacksell, LE Arvidsson, U Svensson…

Index: Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482

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Citation Number: 94

Abstract

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3- hydroxyphenyl)-Nn-propylpiperidine have been synthesized and tested for central dopamineautoreceptor stimulating activity. The 3-(3-hydroxypheny1) piperidine moiety seems indispensable for high potency and selectivity. Introduction of an additional hydroxyl group into the 4 position of the aromatic ring gives a compound with dopaminergic activity ...

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one Structure

1-[3-(3,4-dimet...

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine Structure

3-(3,4-dimethox...

3-Bromopyridine Structure

3-Bromopyridine

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine Structure

3-(3,4-dimethox...

3-(3,4-Dimethoxyphenyl)pyridine Structure

3-(3,4-Dimethox...

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine Structure

3-(3,4-dimethox...

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine Structure

3-(3,4-dimethox...

3-(3,4-dimethoxyphenyl)-1-propylpiperidine Structure

3-(3,4-dimethox...

~85%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide Structure

4-(1-propylpipe...

3-Bromopyridine Structure

3-Bromopyridine

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide Structure

4-(1-propylpipe...

3,4-Dimethoxyphenylmagnesium bromide Structure

3,4-Dimethoxyph...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide Structure

4-(1-propylpipe...

3-(3,4-Dimethoxyphenyl)pyridine Structure

3-(3,4-Dimethox...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide Structure

4-(1-propylpipe...

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide Structure

4-(1-propylpipe...

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one Structure

1-[3-(3,4-dimet...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide Structure

4-(1-propylpipe...

3-Bromopyridine Structure

3-Bromopyridine

~%

3-PHENYLPIPERIDINE Structure

3-PHENYLPIPERIDINE

3-(4-Methoxyphenyl)pyridine Structure

3-(4-Methoxyphe...

~%

3-(4-Methoxyphenyl)piperidine Structure

3-(4-Methoxyphe...

3-Bromopyridine Structure

3-Bromopyridine

~%

3-(4-Methoxyphenyl)piperidine Structure

3-(4-Methoxyphe...

4-Anisylmagnesium bromide Structure

4-Anisylmagnesi...

~%

3-(4-Methoxyphenyl)piperidine Structure

3-(4-Methoxyphe...

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

~70%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide Structure

4-piperidin-3-y...

3-Bromopyridine Structure

3-Bromopyridine

~%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide Structure

4-piperidin-3-y...

3,4-Dimethoxyphenylmagnesium bromide Structure

3,4-Dimethoxyph...

~%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide Structure

4-piperidin-3-y...

3-(3,4-Dimethoxyphenyl)pyridine Structure

3-(3,4-Dimethox...

~%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide Structure

4-piperidin-3-y...

3-Bromopyridine Structure

3-Bromopyridine

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one Structure

1-[3-(3,4-dimet...

3,4-Dimethoxyphenylmagnesium bromide Structure

3,4-Dimethoxyph...

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one Structure

1-[3-(3,4-dimet...

3-(3,4-Dimethoxyphenyl)pyridine Structure

3-(3,4-Dimethox...

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one Structure

1-[3-(3,4-dimet...

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

Propanoyl chloride Structure

Propanoyl chloride

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one Structure

1-[3-(3,4-dimet...

3-Bromopyridine Structure

3-Bromopyridine

m-tolylmagnesium bromide Structure

m-tolylmagnesiu...

~%

3-(3-Methylphenyl)pyridine Structure

3-(3-Methylphen...

3-(3-Methylphenyl)pyridine Structure

3-(3-Methylphen...

~%

ISOCHROMAN-1-YLMETHYL-METHYL-AMINE HYDROCHLORIDE Structure

ISOCHROMAN-1-YL...

3-Bromopyridine Structure

3-Bromopyridine

~%

ISOCHROMAN-1-YLMETHYL-METHYL-AMINE HYDROCHLORIDE Structure

ISOCHROMAN-1-YL...

m-tolylmagnesium bromide Structure

m-tolylmagnesiu...

~%

ISOCHROMAN-1-YLMETHYL-METHYL-AMINE HYDROCHLORIDE Structure

ISOCHROMAN-1-YL...

3-Bromopyridine Structure

3-Bromopyridine

3-Fluorophenylmagnesium bromide solution Structure

3-Fluorophenylm...

~%

3-(3-fluorophenyl)pyridine Structure

3-(3-fluorophen...

3-(3,4-Dimethoxyphenyl)pyridine Structure

3-(3,4-Dimethox...

~%

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

3-Bromopyridine Structure

3-Bromopyridine

~%

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

3,4-Dimethoxyphenylmagnesium bromide Structure

3,4-Dimethoxyph...

~%

3-(3,4-dimethoxyphenyl)piperidine Structure

3-(3,4-dimethox...

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]